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在清醒状态期间,体感体皮质回路的动态皮质体调节
Elaida D Dimwamwa1, Aurélie Pala1,2, Vivek Chundru1
1Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Nature communications
|April 25, 2024
概括
皮层第6层 (L6CT) 神经元动态调节感官 thalamus 活动,影响神经信号传递. 它们的发射速率和同步性决定了它们是否抑制或增强乳头突起,影响皮质刺激性.
科学领域:
- 神经科学是一个神经科学.
- 感官处理 感官处理
- 皮层电路的电路结构
背景情况:
- 从皮层第6层 (L6CT) 到感官丘脑的反投影对于关闭感官信息至关重要.
- 通过L6CT神经元影响thalamic活动的精确机制尚不清楚.
研究的目的:
- 为了因果地阐明L6CT投影对感官丘脑功能影响的全部范围.
- 为了研究L6CT神经元在唤醒小鼠中调节thalamicspiking中的作用.
主要方法:
- 目标探测器记录在醒着小鼠的胡须甲状皮质回路中.
- 对表达L6CT神经元的Channelrhodopsin-2进行光遗传学操纵.
- 多站点电生理记录和L6CT电路的计算建模.
主要成果:
- L6CT神经元作为动态调节器,在thalamus (VPm) 的腹腔后介质核中持续升.
- 通过L6CT神经元抑制或增强VPm尖端,取决于它们的发射速率和同步.
- 对皮层刺激和抑制子群的不同影响表明L6CT反会影响整体皮层刺激性.
结论:
- L6CT反投影在调节感官信号处理方面发挥着重要作用.
- 由L6CT神经元进行的动态调制对在各种行为学上相关的条件下对感官处理有影响.
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