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第三组髓母细胞瘤转录网络在特定域EP300/CBP抑制下崩

Noha A M Shendy1, Melissa Bikowitz2,3, Logan H Sigua4

  • 1Division of Molecular Oncology, Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.

Nature communications
|April 25, 2024
PubMed
概括

用抑制剂向EP300/CBP (希酸转移酶) 的特定领域,在癌症中显示出明显的效应. odomain抑制在第三组脑髓母细胞瘤中表现特别有前途,破坏了重要的遗传网络.

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