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Updated: Jun 27, 2025

Tools to Study the Role of Architectural Protein HMGB1 in the Processing of Helix Distorting, Site-specific DNA Interstrand Crosslinks
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Tools to Study the Role of Architectural Protein HMGB1 in the Processing of Helix Distorting, Site-specific DNA Interstrand Crosslinks

Published on: November 10, 2016

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持续结合非切除的DNA损伤的TFIIH会导致细胞和发育失败

Alba Muniesa-Vargas1, Carlota Davó-Martínez1, Cristina Ribeiro-Silva1

  • 1Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015 GD, Rotterdam, The Netherlands.

Nature communications
|April 25, 2024
PubMed
概括

核酸切除修复 (NER) 的缺陷导致疾病. 由于ERCC1-XPF或XPG损失,长时间的TFIIH与DNA损伤结合,与疾病严重程度相关,并导致发育问题.

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