在大脑发育过程中,在3T时的规范体积和放松时间
David Romascano1,2,3, Gian Franco Piredda4,5, Samuele Caneschi6,4,7
1Department of Radiology, Lausanne University Hospital and University of Lausanne, 1011, Lausanne, Switzerland. david.romascano@protonmail.com.
Scientific data
|April 25, 2024
概括
这项研究引入了一个快速的MRI协议,用于儿童和青少年的定量脑成像. 它为T1,T2和大脑体积提供了规范性发育曲线,使个性化神经发育评估成为可能.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 儿科放射学 儿科放射学
背景情况:
- 目前的临床实践依赖于对神经发育障碍的定性MRI评估.
- 在儿科神经成像中,定量研究结果和个人患者护理之间存在差距.
研究的目的:
- 为了弥合定量神经发育研究和临床实践之间的差距.
- 为儿童大脑评估提供一个易于实施的定量MRI协议.
- 为关键的大脑成像指标建立规范性发育曲线.
主要方法:
- 从73名健康受试者 (3-17岁) 获得的定量T1 (MP2RAGE) 和T2 (GRAPPATINI) 放松数据,使用6分钟的MRI协议.
- 自动量化的白质和灰质体积.
- 计算了T1,T2和儿童大脑兴趣区域 (ROI) 跨年龄体积的规范范围.
主要成果:
- 开发了基于年龄的T1,T2和大脑体积的规范性发育曲线.
- 在儿科大脑ROI中的定量成像指标建立了特定年龄的规范范围.
- 创建了一个具有临床应用规范值的开源数据集.
结论:
- 提供的定量MRI数据集和规范曲线有助于对个别儿科患者的评估.
- 这种方法可以在大脑成熟曲线上准确定位患者,帮助个性化护理.
- 从该协议中获得的定量生物标志物可以提高儿科神经发育中的诊断准确性和治疗规划.
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