严重的皮肤不良反应
Shuen-Iu Hung1,2, Maja Mockenhaupt3, Kimberly G Blumenthal4
1Cancer Vaccine and Immune Cell Therapy Core Laboratory, Department of Medical Research, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.
Nature reviews. Disease primers
|April 25, 2024
概括
严重的皮肤不良反应 (SCAR) 是危及生命的药物过敏综合征. 基因查和向疗法正在推进对这些严重疾病的精确管理.
科学领域:
- 免疫皮肤学 免疫皮肤学
- 药物基因组学 药物基因组学
背景情况:
- 严重的皮肤不良反应 (SCARs) 包括史蒂文斯-约翰逊综合征,有毒表皮解,以及带有eosinophilia和全身症状的药物反应.
- 这些情况是危及生命的,涉及复杂的免疫反应对药物抗原.
研究的目的:
- 审查SCARs的病变发生,遗传关联和不断发展的治疗策略.
- 为了突出SCAR中精度管理的转变.
主要方法:
- 关于SCAR病原,遗传学和治疗的文献综述.
- 对T细胞受体-药物抗原相互作用和免疫细胞参与的分析.
- 检查遗传倾向,药物代谢和辅助因素.
主要成果:
- SCAR病原发生涉及T细胞对人类白细胞抗原呈现的药物抗原的识别.
- 与特定的SCAR表型的遗传关联导致了预防性查.
- 不断发展的治疗方法包括生物药物和针对特定免疫路径的小分子.
结论:
- 了解SCAR病原和遗传因素对于预防和个性化治疗至关重要.
- 精确管理策略正在改变SCARs的治疗环境.
相关概念视频
Skin Diseases and Disorders
3.8K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
3.8K
Hypersensitivities
620
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
620
Burn Injuries
2.5K
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
2.5K
Allergic Drug Reactions
838
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
838
Local Anesthetics: Adverse Effects
414
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
414
Skin Cancer
4.1K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.1K


