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Author Spotlight: Functional Site-Directed Fluorometry in Native Cells to Study Skeletal Muscle Excitability
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由于子单元间的二硫化物桥梁,缺乏感知的受体基础活性

Shumin Ma1, Xueliang Yin1, Jean-Philippe Pin2

  • 1Cellular Signaling Laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Communications biology
|April 25, 2024
PubMed
概括

间子单元二硫化物桥梁维持感应受体 (CaSR) 的不活跃状态,防止构成性活动. 破坏这些桥梁,如在低血症突变中所见,会导致显著的CaSR构成活性.

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