肠道微生物组预测了晚年生活中的认知功能和抑郁症状
A Kolobaric1, C Andreescu2, E Jašarević3,4,5
1Center for Neuroscience, University of Pittsburgh, Pittsburgh, USA.
Molecular psychiatry
|April 25, 2024
概括
肠道微生物组可以预测老年人未来的认知衰退和抑郁症. 特定的微生物特征,如Bifidobacterium和肠道细菌的丰富性,与认知和情绪症状有关.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 老年学是一门学科.
背景情况:
- 认知障碍老年人的抑郁症与痴呆症进展有关.
- 肠道微生物组与当前情绪和认知的关联已知,但其对未来症状的预测能力尚不清楚.
研究的目的:
- 识别反映当前认知和抑郁症状的微生物特征.
- 发现微生物标记物,预测未来的认知能力下降和老年人抑郁症状的增加.
主要方法:
- 收集了来自268名参与者具有不同认知/抑郁症状的临床评估和便样本.
- 利用高分辨率的16S rRNA测序来分析微生物群的多样性,结构和组成.
- 采用线性和弹性净回归来确定微生物组特征与当前/未来症状之间的关联.
主要成果:
- 较大的微生物多样性与较低的当前认知和较高的抑郁症相关 (在非抗抑郁药使用者中).
- 较低的Bifidobacterium丰度与当前认知能力低下有关;较高的GABA降解与更大的抑郁症严重程度有关.
- 未来的认知衰退由较低的Intestinibacter,较低的谷氨酸降解和较高的组胺合成预测;未来的抑郁症状由较低的Bacteroidota和较低的谷氨酸降解预测.
结论:
- 认知功能障碍和抑郁症表现出通过肠道微生物群检测到的明显的生物效应.
- 肠道微生物组可以作为评估和预测老年人认知和精神状态的非侵入性工具.
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