一种饮食共生微生物通过激活瘤巨细胞来扣留铁来增强抗瘤免疫力
Garima Sharma1,2, Amit Sharma1,3, Inhae Kim2
1Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
Nature immunology
|April 25, 2024
概括
食品细菌Lactiplantibacillus plantarum IMB19通过调节巨细胞和铁水平来增强抗瘤免疫力. 这表明,有潜力开发食品食用品作为称为"菌生物"的新型癌症疗法.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 癌症生物学 癌症生物学
背景情况:
- 天生的免疫细胞对于抗瘤反应至关重要,涉及铁等营养素的保存.
- 连体细菌可以调节免疫细胞,但机制尚不清楚.
研究的目的:
- 为了研究食品食用 Lactiplantibacillus plantarum IMB19.19 的抗瘤作用.
- 阐明这种细菌增强抗瘤免疫力的分子机制.
主要方法:
- 利用同源和异源移植的小鼠瘤模型.
- 确定了细菌囊异多聚糖化物作为关键的效应分子.
- 研究了与托尔类受体2 (TLR2) 和巨细胞极化相互作用.
主要成果:
- 乳植物菌植物IMB19显著增加了抗瘤免疫力.
- 细菌的异多聚糖酸作为TLR2连接体起作用.
- 它促进了典型的活跃瘤相关巨细胞,并增强了CD8+ T细胞的反应.
- 巨介导的营养免疫通过利波卡林-2封存铁,诱导瘤细胞死亡和清除.
结论:
- 像L. plantarum IMB19这样的食物食用生物可以被开发为用于癌症治疗的"菌生物".
- 这种细菌采用了一种涉及免疫细胞激活和铁封存的双重机制.
- 提供了一种新的,多层次的癌症治疗策略.
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