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Updated: Jun 27, 2025

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cGAS-Ku80复合体调节两个末端连接子路径之间的平衡

Haiping Zhang1, Lijun Jiang1, Xinyi Du2

  • 1Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.

Cell death and differentiation
|April 25, 2024
PubMed
概括

核循环GMP-AMP合成酶 (cGAS) 平衡了DNA修复路径. 它促进了正规非同类末端连接 (c-NHEJ),同时抑制了替代NHEJ (alt-NHEJ),保持了基因组完整性.

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