预先怀孕的体重不足对产后骨质疏松性骨折的影响:使用日本索赔数据的回顾性队列研究
Kayoko Kaneko1, Maiko Suto2, Eiko Miyagawa3
1Division of Maternal Medicine, Center for Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan. kaneko-ky@ncchd.go.jp.
BMC pregnancy and childbirth
|April 25, 2024
概括
日本妇女怀孕前体重不足与产后骨质疏松性骨折风险增加有关. 在怀孕前保持健康的体重对于母亲的骨健康和婴儿护理至关重要.
科学领域:
- 生殖健康 生殖健康
- 骨的新陈代谢 骨的新陈代谢
- 公共卫生 公共卫生
背景情况:
- 营养不良和体重不足是骨质疏松症的已知的危险因素.
- 在日本,改善体重不足的年轻女性的健康状况是一个重要的医疗问题.
- 关于怀孕前体重不足和产后骨质疏松性骨折之间的联系的研究有限.
研究的目的:
- 调查怀孕前体重不足和产后两年内骨质疏松性骨折的发生率之间的联系.
- 在怀孕前分析骨折风险与体重指数 (BMI) 相比.
主要方法:
- 使用日本全国索赔数据库 (JMDC Inc.) 的回顾性队列研究.
- 分析了来自16684名母亲的数据,这些母亲分娩了他们的第一个单子婴儿 (2006年1月 - 2020年12月).
- 根据疾病代码和医疗程序定义的骨质疏松性骨折;预孕BMI (产前12-36个月) 作为暴露;使用卡普兰-梅尔曲线和考克斯回归分析.
主要成果:
- 51名妇女 (0.31%) 在产后两年内经历了骨质疏松性骨折.
- 肋骨骨折占80%以上的病例,约65%发生在产后第一年后.
- 怀孕前体重不足 (BMI <18.5 kg/m2) 与分娩后骨质疏松性骨折有显著的相关性.
结论:
- 孕前体重管理对于提高产后生活质量至关重要.
- 充足的孕前体重可能会对随后的骨健康产生积极影响.
- 在怀孕前优化母亲的体重可以为更好的新生儿护理环境做出贡献.
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