脑卒中发生率随着糖尿病视网膜病变的严重程度和1型糖尿病的黄斑胀而增加
Marika I Eriksson1,2,3, Kustaa Hietala1,4, Paula Summanen1,3,5
1Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Cardiovascular diabetology
|April 25, 2024
概括
在1型糖尿病患者中,糖尿病视网膜病变的严重程度与中风风险增加有关,即使没有糖尿病病等其他并发症. 这突显了视网膜作为脑血管事件的潜在指标.
科学领域:
- 眼科和神经病学 眼科和神经病学
- 糖尿病并发症研究研究
- 脑血管疾病流行病学
背景情况:
- 视网膜的血管变化可能反映出大脑的健康状况.
- 糖尿病视网膜病变 (DR) 和黄斑是1型糖尿病 (T1D) 中中风风险的潜在指标.
- 在T1D中,DR严重程度和中风风险之间的关联需要评估.
研究的目的:
- 评估1型糖尿病患者糖尿病视网膜病变严重程度和中风风险之间的关联.
- 为了确定糖尿病视网膜病变和黄斑是否表明T1D患者中风风险增加.
- 评估中风风险独立于其他并发症,如糖尿病病.
主要方法:
- 包括1,268名成年FinnDiane研究参与者患有1型糖尿病.
- 使用早期治疗糖尿病视网膜病变研究 (ETDRS) 尺度和临床显著的黄斑 (CSME) 评估了基线糖尿病视网膜病变的严重程度.
- 利用考克斯模型计算中风的调整危险比率 (HR),考虑到包括糖尿病病在内的临床混因素.
主要成果:
- 在平均18.0年的随访期间,发生了130次中风 (96次缺血,34次出血).
- 对中风的调整HR增加与较高的糖尿病视网膜病变严重程度 (非增殖性: 1.79;增殖性: 1.69) 相比,没有非常轻微的视网膜病变.
- 在调整后,临床显著的黄斑 (CSME) 并没有显著增加中风风险.
结论:
- 在1型糖尿病患者中,中风发生率随着糖尿病视网膜病变的严重程度而增加.
- 这种关联独立于并发症,包括糖尿病病.
- 糖尿病视网膜病变的严重程度是1型糖尿病中中风风险的重要独立预测因素.
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