在成年患者的原发性血液性恶性瘤之后的后续恶性瘤
Rosa M Rönkkö1,2,3, Aapeli O Nevala1,4, Janne M Pitkäniemi1,5,6
1Finnish Cancer Registry, Cancer Society of Finland, Helsinki, Finland.
International journal of cancer
|April 26, 2024
概括
患有血液性恶性瘤 (HM) 的患者面临随后癌症的风险增加. 年轻的HM患者具有较高的二次血液癌的相对风险,而老年患者承受较大的绝对负担从固体瘤.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 患有原发性血液性恶性瘤 (HM) 的患者患有随后恶性瘤 (SMN) 的风险较高.
- 了解SMN的模式和风险对于长期的癌症患者护理和监测策略至关重要.
研究的目的:
- 在患有原发性血液性恶性瘤 (HM) 的患者中调查后续恶性瘤 (SMN) 的发生率和模式.
- 根据初级HM诊断时的年龄来区分血液和固体SMN的风险.
主要方法:
- 使用1992-2019年芬兰癌症登记处数据进行的回顾性队列研究.
- 包括45533名年龄在20岁及以上的患者,他们被诊断为初级HM.
- 对中小企业的标准化发病率 (SIR) 和绝对风险过剩 (EAR) 的估计.
主要成果:
- 总共有6076个SMN被确定,包括4604个固体SMN和1472个血液SMN.
- 与固体SMN (SIR 1.5) 相比,血液SMN的相对风险更高 (SIR 4.9),而固体SMN的相对风险更高 (SIR 1.5).
- 年轻的HM患者 (20-39岁) 对血液性SMN的SIR最高,而老年患者 (60-79岁) 对固体SMN面临最高绝对风险 (EAR).
结论:
- 血液性恶性瘤患者患血液性和固体后续癌症的风险增加.
- 监测策略应考虑特定年龄的风险,重点关注年轻患者的血液SMN和老年患者的固体SMN.
- 这些发现强调了对HM幸存者的警,适合年龄的随访护理的需要.
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