使用马尔科夫状态过渡模型与不采取行动相比,对糖尿病前期干预方式的成本节约分析 - - 一个多区域案例研究
Hussain Abdulrahman Al-Omar1,2, Marcin Czech3, Tran Quang Nam4
1Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Journal of diabetes
|April 26, 2024
概括
预防2型糖尿病 (T2D) 是非常重要的. 甲胺延长释放 (ER) 和强化生活方式改变 (ILC) 干预措施在降低T2D发病率和医疗保健成本方面表现有前途,特别是在中等收入国家.
科学领域:
- 卫生经济学 卫生经济学
- 公共卫生政策 公共卫生政策
- 预防医学 预防医学
背景情况:
- 糖尿病前期管理是预防2型糖尿病 (T2D) 和相关成本的全球卫生优先事项.
- 中等收入国家面临T2D流行病的重大风险和预防策略的实施挑战.
- 现有的预防研究主要来自发达国家.
研究的目的:
- 评估各种糖尿病前期管理策略的成本效益,在患病率高的国家和经济地位不同的国家.
- 在15年的时间里,比较"不采取行动"与"干预"的场景.
主要方法:
- 用马尔科夫队列模拟来建模成本和收益.
- 分析了三个国家 (波兰,沙特阿拉伯,越南) 的高糖尿病前期流行率和对比的经济.
- 干预包括甲胺延长释放 (ER),强化生活方式改变 (ILC) 和它们的组合,包括定位.
主要成果:
- 没有采取行动导致T2D相关的医疗保健成本最高 (9%-34%的总成本).
- 所有干预措施与不采取行动相比,都减少了T2D发病率;ILC + 甲福林 (ER) 定位是最有效的 (5年后减少39%).
- 仅梅特福林 (ER) 能带来净节约,而其他干预措施的相对成本随着时间的推移而下降. 越南对成本和参数变化表现出高度敏感.
结论:
- 甲胺 (ER) 和生活方式干预有望减少T2D发病率和医疗保健支出.
- 甲胺 (ER) 为减少T2D患者数量和成本提供了一个可行的选择,特别是考虑到对生活方式干预的坚持和资金挑战.
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