一个横向和纵向研究老年男性人口老龄化甲状腺功能的变化
Renfei Zhang1, Juan Dong1, Yuepeng Li1
1Healthcare Department, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, 100730, Beijing, China.
Discovery medicine
|April 26, 2024
概括
老年男性的甲状腺功能随着年龄的增长而变化,在老年人群中,TSH较高,FT3较低. 纵向和横截面分析显示,随着时间的推移,甲状腺功能趋势有所不同,强调了个体在衰老中的变化.
科学领域:
- 内分泌学 在内分泌学.
- 老年病的医生 老年病的医生
- 甲状腺研究 甲状腺研究
背景情况:
- 有限的纵向研究存在于同一个人长时间内的甲状腺功能变化.
- 了解老年男性与年龄相关的甲状腺功能转变对于临床管理至关重要.
研究的目的:
- 为了追溯分析8年期间老年男性的甲状腺功能变化.
- 探索老龄化对正常基线甲状腺功能的男性甲状腺功能参数的影响.
主要方法:
- 从2013年到2020年,对354名老年男性的体检记录进行了回顾性分析.
- 研究对象被分为四个年龄组 (<60,60-69,70-79,≥80岁).
- 甲状腺刺激激素 (TSH),反向三甲状腺素 (rT3),自由三甲状腺素 (FT3) 和自由甲状腺素 (FT4) 水平的横截面和纵向比较.
主要成果:
- 最初的分析显示,年龄与FT3负相关,与RT3和TSH正相关.
- 纵向分析显示,与年轻人相比,≥80岁组的TSH显著更高.
- FT3水平显示下降,然后增加的趋势,而FT4随年龄的变化是不清楚的;rT3随年龄增加在老年人群中.
结论:
- 老年男性的甲状腺功能指数呈现年龄相关的变化,具有明显的横截面和纵向模式.
- 最年长的组 (≥80岁) 呈现出最高的TSH和最低的FT3值.
- 随着年龄的增长,甲状腺功能变化的个体变化需要在临床实践和研究中仔细考虑.
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