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加快的生物衰老是类风湿性关节炎的潜在危险因素
Yi-Lin Dan1,2, Yi-Qun Yang1,2, Dong-Cheng Zhu3
1Collaborative Innovation Center for Bone and Immunology between Sihong Hospital and Soochow University, Center for Genetic Epidemiology and Genomics, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China.
通过生物衰老加速 (BAA) 测量加速的生物衰老与增加类风湿性关节炎 (RA) 风险有关. 这项研究使用英国生物库数据和遗传分析探索了这种联系.
科学领域:
- 生物医学科学 生物医学科学
- 遗传学 是一个遗传学.
- 类风湿病学 类风湿病学
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性自身免疫性疾病.
- 生物衰老和RA病原体之间的关系尚未完全理解.
- 生物衰老标志物可能为RA易感性提供新的见解.
研究的目的:
- 研究生物衰老加速 (BAA) 与类风湿性关节炎 (RA) 风险之间的关联.
- 探索生物衰老和RA之间的关系的遗传基础.
- 确定可能与加速衰老和RA相关联的生物机制.
主要方法:
- 利用英国生物库和遗传数据集来分析生物年龄的两个指标:PhenoAge和BioAge.
- 计算生物年龄加速 (BAA) 作为从时间年龄计算生物年龄的余量.
- 雇佣的遗传风险得分 (GRS),链接不平衡得分回归 (LDSC) 和PLACO分析.
主要成果:
- 发现BAA与发展RA和血清阳性RA的风险之间存在正相关性.
- 对PhenoAge加速的遗传风险评分与RA风险增加有关.
- 在LDSC分析中,PhenoAge加速和RA之间存在积极的遗传相关性,PLACO识别了类基因.
结论:
- 通过BAAs指出的加速生物衰老与类风湿性关节炎易感性正相关.
- 遗传因素有助于加速衰老和RA之间的联系.
- 这些发现为了解将衰老与RA联系在一起的机制提供了基础.
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