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Updated: Jun 27, 2025

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
07:09

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Published on: January 7, 2019

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测试CRL4DCAF12与MAGEA3和CCT5二C终端降解子的相互作用

Germanna Lima Righetto1,2, Yanting Yin3, David M Duda3

  • 1Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.

PNAS nexus
|April 26, 2024
PubMed
概括

损坏的DNA结合蛋白-1 (DDB1) 和CUL4关联因子12 (DCAF12) 识别了MAGEA3和CCT5蛋白的C终端降解子. 一个冷EM结构揭示了DCAF12结合相互作用,使新的药物开发策略成为可能.

关键词:
CCT5 CCT5 CCT5 CCT5 CCT5 CCT5 CCT5 CCT5 CCT5 CCT5 CCT5在 DCAF12 中使用.E3 结合酶的使用马盖亚3 在马盖亚3这就是PROTAC.

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