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区域同质性作为早产婴儿感官皮层不成熟的标志物
Srikanth R Damera1, Josepheen De Asis-Cruz1, Kevin M Cook1
1Developing Brain Institute, Children's National, 111 Michigan Avenue NW, Washington, DC 20010, USA.
iScience
|April 26, 2024
概括
早产改变了感官皮层的发育,减少了大脑的连接性. 这可能会增加神经发育障碍的风险,包括自闭症,在婴儿暴露于早期的子宫外环境.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 新生儿科学 新生儿科学
背景情况:
- 早产婴儿的非典型感官体验可能导致神经发育障碍.
- 感官皮层发育的改变是将早产与这些残疾联系起来的潜在机制.
研究的目的:
- 研究早期子宫外暴露对早产婴儿感官皮层发育的影响.
- 通过使用区域同质性 (ReHo) 评估早产婴儿和早产婴儿之间的局部大脑连接的差异.
主要方法:
- 休息状态功能磁共振成像 (fMRI) 数据从早产婴儿和早产婴儿中收集.
- 分析了区域同质性 (ReHo),这是地方功能连接的衡量标准.
- 婴儿在月经后32至48周之间进行了扫描.
主要成果:
- 雷霍在整个大脑的分布反映了皮层成熟的既定梯度.
- 过早分娩与ReHo在主要感官皮层的差异性减少有关.
- 在早产婴儿的听觉皮层中减少的ReHo与18个月的自闭症风险更高相关.
结论:
- 感官皮层内的局部功能连接表现出不同的发展轨迹.
- 过早分娩显著影响感官皮层发育和局部连接.
- 在早产婴儿中,感官皮层连接的改变可能与以后的神经发育结果有关,包括自闭症.
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