在F2后代中检测到怀孕期间母亲饮食不良的影响
N M Tillquist1, S A Reed1, A S Reiter1
1University of Connecticut, Department of Animal Science, Storrs, CT 06269, USA.
Translational animal science
|April 26, 2024
概括
奶奶母羊的母亲营养不良会影响F2后代的生长,对料效率,葡萄糖耐受性和瘦素水平的影响很小. 这凸显了营养对后代发育的跨代影响.
科学领域:
- 生殖生物学 生殖生物学
- 动物科学动物科学
- 营养科学 营养科学
背景情况:
- 母亲的营养显著影响后代的发育和代谢健康.
- 营养状况在几代人的跨世代影响还没有完全被理解.
- 以前的研究表明,母亲营养不良会影响F1后代的生长和新陈代谢.
研究的目的:
- 调查母 (F0) 营养对F2后代生长,料效率,葡萄糖耐受性和瘦素水平的影响.
- 为了确定怀孕期间的营养侮辱是否会对第二代产生持久的影响.
- 评估祖母饮食对F2公羊形态学和骨矿物质密度的影响.
主要方法:
- 在怀孕期间,F0羊被养100% (控制),60% (限制) 或140% (过度养) 的NRC需求.
- 这些母羊的F1后代被繁殖,以产生F2后代.
- 监测F2后代的生长,体重,血清瘦素和葡萄糖耐受性.
- 在F2公羊中评估了剩余料摄入量 (RFI),身体形态学和骨矿物质密度.
主要成果:
- 限制养祖母的F2后代 (RES-F2) 倾向于从第84天起体重较低,与对照组相比 (CON-F2).
- 奶奶的饮食没有显著影响F2公羊的形态,器官重量或骨矿物质密度.
- 与CON-F2.2相比,RES-F2和OVER-F2后代在56天表现出明显较低的血清瘦素水平.
- 葡萄糖耐受性和RFI对祖母的营养状况的影响很小,尽管CON-F2公羊的葡萄糖峰值更高.
结论:
- 母亲的营养不良会影响后代的成长到第二代.
- 在这个模型中,对料效率和葡萄糖耐受性的跨代营养影响似乎很小.
- 在F2后代中,循环中的瘦素水平对祖母的营养状况敏感,这表明潜在的长期代谢编程.
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