在精神疾病中减少同位素半球间连接:证据表明跨诊断和疾病特征
Shuxia Yao1, Keith M Kendrick1
1The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu 611731, China.
Psychoradiology
|April 26, 2024
概括
大脑半球同位素功能连接性下降在许多精神疾病中很常见,可能作为精神病理学的一般标志物. 然而,具体模式有所不同,特别是在自闭症谱系障碍和注意力缺陷多动障碍之间存在显著差异.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 大脑的连接性 大脑的连接性
背景情况:
- 半球间的结构和功能连接对于正常的大脑功能至关重要,并与精神疾病有关.
- 休息状态fMRI数据的Voxel镜像同位素连接 (VMHC) 分析越来越多地用于研究这些连接.
研究的目的:
- 审查和综合来自VMHC研究的各种神经精神疾病的研究结果.
- 探索同位素连接的潜力,作为精神病理学的跨诊断标记.
主要方法:
- 发表的voxel镜像同位素连接性研究的系统综述.
- 分析的重点是不同疾病的同位体大脑区域的静止状态功能连接.
主要成果:
- 大多数审查的精神疾病 (不包括ADHD) 在多个网络中显示同位素静止状态功能连接性下降.
- 这些下降通常与症状严重程度和疾病持续时间有关,这表明跨诊断的作用.
- 与其他疾病相比,在自闭症谱系障碍和精神分裂症中观察到明显的连接性减少模式.
结论:
- 降低同位素静止状态功能连接性可能代表一般精神病理学的跨诊断生物标志物.
- 需要进一步的研究来了解这些联系在健康和疾病中的功能意义,重点关注一般的精神病理学和疾病特异性症状.
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