果叶提取物对健康成年人认知功能的急性影响:一个随机,双盲,安慰剂控制的交叉研究
Fiona L Dodd1, David O Kennedy1, Jodee Johnson2
1Brain, Performance, Nutrition Research Centre, Department of Psychology, Northumbria University, Newcastle upon Tyne, United Kingdom.
Frontiers in nutrition
|April 26, 2024
概括
叶提取物 (MLE) 在健康成年人中没有显著改善认知表现或情绪. 虽然注意到一些增加的错误,但这些发现需要谨慎,因为它们的有限性质.
科学领域:
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
- 营养保健品 营养保健品
背景情况:
- 果叶提取物 (MLE) 富含曼吉费林,有着悠久的药用历史.
- 以前的研究表明,MLE可能对动物和人类的认知功能产生积极影响.
研究的目的:
- 为了评估300毫克的MLE剂量 (标准化为≥60%mangiferin) 对健康成年人的认知表现和情绪的影响.
- 为了评估30分钟,180分钟和300分钟后的认知和情绪变化.
主要方法:
- 这是一项双盲,安慰剂控制,交叉研究,涉及114名健康参与者 (18-43岁).
- 参与者在两个单独的测试访问期间接受了MLE或安慰剂.
- 认知表现,包括认知需求电池和情绪在多个时间点被评估.
主要成果:
- 与安慰剂相比,在MLE组中观察到序列3s和7s减去错误的显著增加.
- 没有检测到认知表现的其他显著改善.
- 报告没有关于情绪的显著影响.
结论:
- 在没有多任务压力因素的健康成年人中,急性摄入300毫克的MLE并没有提高认知表现或情绪.
- 观察到的减法误差的增加是最小的,应谨慎解释.
- 可能需要进一步的研究来探索在不同的条件下潜在的认知益处.
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