时差对大脑白质功能连通性的影响
Feifei Zhang1,2, Zhipeng Yang3, Kun Qin1,2
1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, China.
Psychoradiology
|April 26, 2024
概括
长途飞行带来的时差会改变传感机动网络中的白质功能连接 (FC). 这些影响静态和动态连接的变化与情绪健康相关,突出了时差差.
科学领域:
- 神经科学是一个神经科学.
- 睡眠医学 睡眠医学
- 放射学 放射学是一门学科.
背景情况:
- 跨越多个时区的长途飞行可以诱导昼夜节律睡眠障碍,通常称为时差.
- 时差对白质 (WM) 功能连接 (FC) 的影响仍然在很大程度上未被探索.
- 了解这些影响对于理解被破坏昼夜节律的更广泛的生理和心理后果至关重要.
研究的目的:
- 为了调查白质 (WM) 功能连接 (FC) 在跨大陆旅行后从时差中恢复后发生的变化.
- 检查WM FC和功能共变量连接 (FCC) 的静态和动态变化.
- 为了探索时差差引起的神经变化和情绪状态之间的关系.
主要方法:
- 休息状态功能磁共振成像 (fMRI) 在长途飞行前和50天后在23名参与者中使用.
- 白质 (WM) 和灰质 (GM) 网络使用k-means集群识别.
- 分析了静态和动态WM FC和FCC,并使用验证的问卷进行了情感评估.
主要成果:
- 参与者证实有时差症状表现出几个WM网络之间的静态和动态FC减少,包括带膜网络 (WM7) 和传感运动网络,与恢复相比,飞行后.
- 功能共变连接 (FCC) 分析显示WM7与其他大脑网络之间的连接减少,特别是前中心/后中心网络.
- 在感觉运动区域内,在情绪分数和FC之间观察到显著的负相关性.
结论:
- 时差与静态和动态白质 (WM) 功能连接 (FC) 和功能共变连接 (FCC) 的显著变化有关,特别影响传感运动网络.
- 这些发现强调,时差是一种复杂的疾病,超出睡眠节律的干扰,影响情绪调节.
- 该研究证实了WM网络在昼夜节律中断的背景下存在和相关性.
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