肺移植后高灵敏度热素水平的影响
Eduard Rodenas-Alesina1,2, Adriana Luk1,2, John Gajasan3
1Division of Cardiology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
概括
肺移植 (LT) 后高灵敏性心脏托罗素I (hs-cTnI) 是常见的,并与并发症有关. 升高的hs-cTnI预测了长时间的机械通风,心律失常和LT接受者的住院死亡.
科学领域:
- 心脏病学 心脏病学
- 胸部外科手术 胸部外科手术
- 移植医学 移植医学
背景情况:
- 肺移植 (LT) 后高灵敏性心脏托罗素I (hs-cTnI) 的临床意义尚不清楚.
- 了解hs-cTnI动力学及其对结果的影响对于管理LT患者至关重要.
研究的目的:
- 研究LT后hs-cTnI的趋势和临床价值.
- 确定影响hs-cTnI水平的因素及其与患者结果的相关性.
主要方法:
- 一项回顾性研究包括2015-2017年期间的206名LT接受者.
- 在LT后0-24小时,24-48小时和48-72小时测量Hs-cTnI水平.
- 主要结局是侵袭性机械通风 (IMV) >3天;其他结局包括心律失常和住院死亡.
主要成果:
- 几乎所有患者 (99%) 符合术后心肌梗塞的标准,中位数峰值hs-cTnI为4,820 ng/mL.
- 峰值hs-cTnI与右心室功能障碍,输血,双边LT,EVLP使用,功能和心肺支持续时间相关.
- 较高的hs-cTnI峰值与长时间的IMV (>3天),心房律乱和住院死亡率有关.
结论:
- 后LT hs-cTnI升高受到接受者的并发症和术后因素的影响,而不是冠状动脉疾病.
- Hs-cTnI是一种有价值的生物标志物,用于识别具有较高风险的长期IMV,心律失常和不良住院结果的LT患者.
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