尿甲酸盐和甲酸盐代谢物与癌症风险之间的关联:系统性审查和元分析
Meng Meng1,2, Yao Yang3, Liang Song4
1Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.
Heliyon
|April 26, 2024
概括
这项研究发现,在工业产品中常见的某些酸盐及其代谢物暴露与癌症风险增加有关. 分析强调了尿路甲酸盐与癌症发展之间存在显著的联系.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 在瘤学瘤学.
背景情况:
- 酸盐是广泛使用的工业化学品,被称为内分泌干扰化学品 (EDC).
- 之前关于酸盐,其代谢物和癌症风险之间的联系的研究已经产生了不一致的结果.
- 需要进行全面的评估,以澄清甲酸盐暴露与癌症发展之间的关联.
研究的目的:
- 进行一项元分析,评估甲酸盐及其代谢物与癌症风险之间的关联.
- 确定测量酸盐或其代谢物的原始研究,并报告与癌症的相关性.
- 为了更清楚地了解甲酸盐暴露与癌症发展之间的关系.
主要方法:
- 进行了全面的文献搜索,以确定相关的原始研究,直到2023年7月4日.
- 包括几率比率 (OR) 和95%置信区间 (CI) 在内的数据从11项研究中提取.
- 分析了来自3101名癌症患者和6858名对照组的数据,使用固定或随机效应模型.
主要成果:
- 在比较极端类别时,观察到尿甲酸盐和甲酸盐代谢物 (MEHHP,MECPP,DBP和MBzP) 与癌症风险之间存在显著的关联.
- 分析结果强化了现有的证据,将尿路甲酸盐及其代谢物与癌症发展联系起来.
- 特定的甲酸盐代谢物,如MEHHP,MECPP,DBP和MBzP,与癌症风险增加有显著的相关性.
结论:
- 尿路酸盐及其代谢物与癌症的发展密切相关.
- 需要进一步的研究来阐明这种关联背后的具体机制.
- 这些发现提供了关于酸盐在癌症病因学中的作用的新见解.
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