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在阿尔茨海默氏病中,皮层厚度的模式是潜在的破坏性行为

Raymond M Xiong¹, Teng Xie², Haifeng Zhang²

¹Experimental High School Attached to Beijing Normal University, Beijing 100032, China.

Psychoradiology

|April 26, 2024

概括

阿尔茨海默病 (AD) 患者的破坏性行为与感官,运动和语言区域的皮质厚度降低有关. 这一发现可能会为管理AD中这些具有挑战性的症状的新干预措施提供信息.

科学领域:

神经科学是一个神经科学.
神经学神经学
医疗成像医学成像

背景情况:

阿尔茨海默氏症 (AD) 经常表现为干扰性行为,如兴奋和易怒.
对于阿尔茨海默氏症中这些行为的潜在神经解剖学基础仍然不完全理解.

研究的目的:

为了比较AD患者和健康对照者的皮层厚度和表面积.
研究AD患者皮质结构和破坏性行为之间的关联.

主要方法:

使用CIVET管道分析了结构性MRI扫描,以检测皮质厚度和表面积.
174名参与者 (125名阿尔茨海默病患者,49名对照人) 使用神经精神病学库存进行了破坏性行为评估.
一般线性模型用于组比较和大脑行为分析,控制年龄,性别和教育程度.

主要成果:

与对照人群相比,AD患者的皮质厚度普遍减少,特别是在部和部区域,左侧状回形和下回形的表面积较小.
较高的破坏性行为得分与感觉运动,语言和表达相关区域的皮质稀释有显著相关.
破坏性行为和皮质表面积之间没有发现显著的关联.

结论:

阿尔茨海默氏症的破坏性行为与感官,运动和语言处理领域的皮质厚度减少特别相关.
这些发现提供了对AD中破坏性行为的神经解剖学基质的见解.
结果表明,有可能开发有针对性的基于感官,运动和通信的干预措施.

关键词:

阿尔茨海默氏症的疾病是阿尔茨海默氏症.这就是CIVET算法.破坏性行为破坏性行为皮层厚度皮层厚度磁共振成像 (MRI) 的使用.表面积面积面积面积面积面积面积面积面积面积

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