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使用多变量评分系统预测细胞内的精子注射周期的生殖结果
Ahmed Abuelsoud Abden1, Momen Ahmed Kamel1, Ahmed Nabil Fetih1
1Department of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, Asyut, Egypt.
Journal of human reproductive sciences
|April 26, 2024
概括
尤尼斯分数准确地预测了细胞内质精子注射 (ICSI) 的成功,识别了怀孕率和活产率较高的患者. 这种评分系统有助于在ICSI治疗前为患者提供咨询,以了解他们活产的真实机会.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 不孕症治疗 不孕症治疗
- 生物统计学 生物统计学
背景情况:
- 预测体外受精 (IVF) /细胞内精子注射 (ICSI) 的成功对于患者咨询至关重要.
- 结合内分泌,临床和超声波参数的Younis多变量得分是已知的IVF/ICSI成功预测模型.
研究的目的:
- 评估Yunis多变量得分在ICSI周期中对怀孕结果的预测准确度.
- 为了验证尤尼斯分数能够预测ICSI周期成功率和取消率的能力.
主要方法:
- 一项前性观察队列研究包括2019年2月至2021年12月期间的292个ICSI-ET周期.
- 优尼斯分数是使用包括年龄,BMI,毛囊数量,FSH,FSH/LH比率,不孕持续时间,以前的取消和卵巢体积在内的变量来计算的.
- 统计分析包括t测试,曼-惠特尼测试,奇方测试,ROC曲线分析和多变量逻辑回归.
主要成果:
- 与高得分 (>14) (分别为7.4%和6.7%) 相比,低尤尼斯分数 (≤14) 的女性的怀孕率 (60.1%) 和活产率 (44.7%) 显著更高.
- 经过ROC分析,得分的可预测性很好,AUC为0.829的怀孕和0.796的活产率,切断值为≤14.
- 低分数与冷胚胎可用性的可能性更高相关,而高分数表明周期取消的可能性更高.
结论:
- 尤尼斯多变量得分有效预测ICSI周期结果,包括取消,怀孕和活产率.
- 该分数作为治疗前咨询的宝贵工具,帮助患者了解他们成功活产的概率.
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