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Updated: Jun 27, 2025

Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology
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Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology

Published on: March 31, 2022

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使用人工智能增强的综合生物物理研究,准确地描述HSP90护手抑制剂的结合动力学和Allosteric机制

Chao Xu1, Xianglei Zhang1, Lianghao Zhao1

  • 1Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai 201210, China.

JACS Au
|April 26, 2024
PubMed
概括

定量结构-动力学关系模型预测了热冲击蛋白90α抑制剂的药物标结合动力学. 这些模型通过评估药物位的停留时间和了解分子机制,有助于发现新药.

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