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Updated: Jul 26, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
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以三酸为媒介的合成桑构造物及其广泛的抗结核评估

Bisma Teli1,2, Mohamad Mosa Mubarak2,3, Zahoor Ahmad2,3

  • 1Natural Products and Medicinal Chemistry, CSIR-IIIM Sanatnagar Srinagar 190005 India bilal@iiim.res.in.

RSC medicinal chemistry
|April 26, 2024
PubMed
概括

新的1,8-dioxohexahydroxanthenes显示出强大的抗结核活性. 化合物14c和14r对Mycobacterium结核病有效,并与现有的药物协同工作.

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Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...