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下皮层默认模式网络和阿尔茨海默病:系统性审查和元分析

Sara Seoane^1,2,3, Martijn van den Heuvel^1,4, Ángel Acebes^2,5

¹Department of Complex Traits Genetics, Center for Neurogenomics and Cognitive Research (CNCR), Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, The Netherlands.

Brain communications

|April 26, 2024

概括

默认模式网络 (DMN) 在健康成年人中包括皮质下区域,如丘脑和杏仁体. 阿尔茨海默病改变了DMN连接,特别是在中间叶和杏仁体.

科学领域:

神经科学是一个神经科学.
脑部成像脑部成像
神经退行性疾病神经退行性疾病

背景情况:

默认模式网络 (DMN) 是一个关键的大脑网络,与各种疾病有关.
它在阿尔茨海默病 (AD) 中的作用和脆弱性是重要的研究领域.
皮下DMN的参与及其在阿尔茨海默病中的变化尚未得到充分理解.

研究的目的:

在健康成年人中系统地审查和验证皮下DMN区域.
在阿尔茨海默病中使用元分析和网络分析分析皮质下DMN变化.
阐明AD中DMN功能障碍的神经生物学基础.

主要方法:

在健康成年人中对皮下DMN进行系统审查和元分析.
在阿尔茨海默病中对皮下DMN进行系统审查,元分析和网络分析.
功能连接分析以识别改变的DMN区域.

主要成果:

该DMN始终包括皮下区域:大脑丘脑,小脑 (叶片, IX,Crus I/II) 和杏仁体.
网络分析表明尾状核参与DMN.
阿尔茨海默病显示左侧中间叶和杏仁核中的功能连接性下降,与DMN重叠.
在阿兹海默症患者的右前胰岛中观察到功能连接的增加.

结论:

皮下结构对健康个体的DMN有显著的贡献.
皮下DMN的变化与阿尔茨海默病的病理生理学有关.
这些发现强调了研究皮下DMN在AD等神经退行性疾病中的重要性.

关键词:

阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.默认模式网络模式默认模式网络模式功能连接性的功能连接性皮质下皮层的皮质下皮层.

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