在2岁的早产儿中,在术语相当的年龄和语言中的结构连接性得到了纠正
Maria E Barnes-Davis1,2, Brady J Williamson3, Julia E Kline1
1Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Brain communications
|April 26, 2024
概括
极度早产的婴儿表现出大脑连接的改变. 在术语相当年龄时,大脑后部区域的更强的连接性与经过2年校正的年龄与较差的语言发育有关.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 儿科神经学 儿科神经学
背景情况:
- 之前的研究表明,在极度早产婴儿 (<28周) 中,异常的半球间结构性超连接性绕过体,与以后的语言技能积极相关.
- 这项研究研究了在极度早产的婴儿中,没有明显的脑损伤的情况下,外连接的发育轨迹.
研究的目的:
- 为了确定是否在相当于期限的极度早产婴儿中存在外状白质通路.
- 评估这种连接性对22-26个月校正年龄的语言发展的预测价值.
主要方法:
- 利用了来自辛辛那提婴儿神经发育早期预测研究的95名极度早产婴儿的前队列,没有明显的脑损伤.
- 在期同等年龄 (39-44周月经后年龄) 采用高阶扩散MRI建模 (一般化q采样成像和受约束的球形解卷).
- 进行了结构连接测量和基于连接性的固定增强分析,将白质连接与2岁校正年龄的语言分数相关联,控制共变量.
主要成果:
- 结构连接测量揭示了语言得分与双边小脑白质,中间小脑脚,皮质脊髓管道,后部指导管和后部下部前后带之间的反向相关性.
- 经过多次比较纠正后,使用受约束的球形解卷/基于连接的固定增强方法没有发现任何显著的关联.
- 这些发现表明,在相当于年龄的特定后白质道的连接性增加可能对随后的语言发育不利.
结论:
- 这项研究提供了关于极度早产婴儿中支持语言的结构性大脑网络早期发展的见解.
- 大脑后部区域,包括小脑通路在内的更大的连接性,在相当年龄时与较差的语言结果有关.
- 这些发现强调了早期大脑结构和神经发育轨迹在这个脆弱人群之间的复杂关系.
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