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副海马皮层中异常的马相振幅合与阿尔茨海默氏病中的网络过度兴奋性有关

Pooja Prabhu^1,2, Hirofumi Morise^1,3, Kiwamu Kudo^1,3

¹Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA.

Brain communications

|April 26, 2024

概括

阿尔茨海默氏症患者在副海马皮质中显示了马相振幅合 (PAC) 的减少,这表明神经活动发生了变化. 这种减少在患有型活动的患者中更为明显,这表明阿尔茨海默氏症患者的网络过敏性.

科学领域:

神经科学是一个神经科学.
生物标志物生物标志物
人类大脑成像技术

背景情况:

在阿尔茨海默病 (AD) 的动物模型中观察到改变的马振荡 (∼40 Hz).
阶段振幅合 (PAC) 通过低频相调节量化马活性,作为神经元刺激性的指数.
中间叶区域,包括脑内皮层和副海马体,容易受到早期AD病理生理学的影响.

研究的目的:

在AD患者中使用玛PAC调查局部神经元活动和兴奋性.
在临床AD群体中,与对照组相比,检查内皮层和副海马体内的马PAC.

主要方法:

在50名AD患者和35名年龄相匹配的对照中,利用磁脑电图 (MEG) 与EEG同时进行.
计算的玛PAC (30-40赫兹的振幅与4-12赫兹的阶段相结合) 在内腔和副海马皮层.
根据型活动的存在 (AD-EPI+) 或不存在 (AD-EPI-) 进行了AD患者的分类.

主要成果:

与对照人群相比,阿尔茨海默病患者在左侧准海马皮质中呈现出减少的玛PAC.
与AD-EPI-患者相比,AD-EPI+患者的双边副海马 gamma PAC显著减少,比AD-EPI-患者大.
在AD患者的内腔皮层中没有发现显著的玛PAC异常.

结论:

副海马皮层中的减少的玛PAC反映了AD早期特定区域网络过敏性.
PAC是神经网络过度兴奋的敏感指标,特别是在患有型活动的阿兹海默症患者中.
调查神经回路过敏性对于理解AD病理生物学和开发潜在的治疗点至关重要.

关键词:

阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.马振荡的马振荡磁脑脑摄影 (MEG) 是一种磁脑脑摄影 (MEG) 技术.网络的过度刺激性.阶段-振幅合器的相位-振幅合

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