1型糖尿病和COVID-19:文献综述和可能的管理方法
Kebria Kashfi1, Narges Anbardar2, Artin Asadipooya3
1Department of Clinical Medicine, Florida International University AUACOM, Florida, USA.
International journal of endocrinology and metabolism
|April 26, 2024
概括
COVID-19大流行可能不会增加1型糖尿病 (T1D) 发病率,但与T1D患者更频繁和更严重的糖尿病酸性脂肪酸 (DKA) 有关. 这表明需要替代治疗策略超越抗病毒药物对内分泌并发症.
科学领域:
- 内分泌学和传染病的研究
- 代谢障碍和病毒感染
背景情况:
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 可能会损害内分泌功能,导致甲状腺功能障碍和高血糖症等并发症.
- 据怀疑,2019年冠状病毒病 (COVID-19) 流行病增加了1型糖尿病 (T1D) 和其严重并发症的发生率,例如糖尿病酸性脂肪酸症 (DKA).
研究的目的:
- 自COVID-19大流行开始以来,系统地审查有关T1D和相关并发症的发病率的现有数据.
主要方法:
- 使用PubMed和谷歌学者进行了全面的文献审查.
- 关键词包括"T1D,T1DM,1型DM或1型糖尿病"和"冠状病毒,SARS-CoV-2或COVID-19".
- 研究选择涉及选标题和摘要,然后对相关文章进行全文审查.
主要成果:
- 在304项已识别的研究中,有25项被选中进行分析,15项是多中心或全国性的.
- 在全球范围内,有关T1D发病率,住院和死亡率的数据各不相同.
- 然而,在COVID-19大流行期间,T1D患者的DKA的发病率和严重程度似乎更高,而不管T1D发病率的潜在增加.
结论:
- COVID-19对T1D发病率的影响仍然不确定,但它与T1D患者的DKA发病率和严重程度增加有关.
- 这表明,目前的抗病毒治疗可能无法完全预防SARS-CoV-2引起的内分泌并发症.
- 建议采用另一种治疗方法,可能涉及抑制病毒进入和调节免疫反应的药物,用于管理COVID-19的内分泌后续.
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