肺癌患者的血组织因子活性预测静脉血栓栓塞和整体存活率差
Helene Doubre1, Isabelle Monnet2, Reza Azarian3
1Service de Pneumologie, Hôpital Foch, Suresnes, France.
Research and practice in thrombosis and haemostasis
|April 26, 2024
概括
血组织因子活性 (TFA) 和D-二次体水平可以预测肺癌患者的静脉血栓栓塞 (VTE) 风险. 诊断时高的TFA水平表明VTE的风险更高,存活率更差.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 生物化学 生物化学
背景情况:
- 肺癌 (LC) 患者面临高风险的静脉血栓栓塞 (VTE).
- 需要有效的生物标志物来识别高风险的LC患者,以预防VTE.
- 早期识别VTE风险可以改善患者的治疗结果.
研究的目的:
- 评估血组织因子活性 (TFA) 和D-二次体水平对LC患者VTE发生的预测值.
- 评估这些生物标志物与LC患者的整体存活率的相关性.
- 为了确定TFA和D-二次体对VTE风险分层的最佳切断值.
主要方法:
- 对302名连续LC患者进行的前性多中心观察队列研究.
- 在诊断时 (V1) 和诊断后8-12周 (V2) 测量的血TFA和D-二次体水平.
- 统计分析,包括多变量分析,以确定VTE和生存的重要预测因素.
主要成果:
- 38名 (12.6%) 患者在一年内发生了静脉瘤.
- 在3个月内发生VTE的患者中,V1-TFA和V1-D-二次体水平显著增加.
- V1-TFA > 1.92 ng/mL是1年VTE风险的唯一显著预测因素 (HR 2.10; P = .03).
- 升高的V1-TFA和V1-D-二次体水平与明显更差的整体存活率有关.
结论:
- 诊断时血TFA水平升高与3个月内静脉瘤风险增加有关.
- 血TFA和D-二聚合物水平作为预测VTE和肺癌患者整体存活率的宝贵生物标志物.
- 监测TFA水平可以有助于在LC中对VTE的风险分层和管理.
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