区域表面杏仁体休息状态功能连接在成年人中会导致童年虐待的严重程度
Qi Liu1, Xinwei Song1, Xinqi Zhou2
1The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 611731, China.
Psychoradiology
|April 26, 2024
概括
童年虐待对表面杏仁核连接有负面影响,特别是与pgACC和PCG. 这些大脑变化可能作为虐待相关的精神疾病如抑郁和焦虑的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 儿童虐待 (CM) 与成人神经精神疾病和大脑发育的改变有关.
- 杏仁体的功能连接性与CM有关,但研究结果不一致.
- 杏仁体休息状态功能连接 (rsFC) 的差异性改变可能解释这些不一致性.
研究的目的:
- 调查杏仁体亚区域rsFC和CM严重程度之间的关系.
- 开发一个稳定的基于rsFC的模型来推断CM的严重程度.
主要方法:
- 使用童年创伤问卷 (CTQ) 评估CM严重程度.
- 在发现数据集 (n=110) 中,与CM相关的杏仁体子区域 (CMA,BLA,SFA) 的探索 rsFC.
- 在使用线性回归和支向量回归的独立复制数据集 (n=38) 中验证的结果.
主要成果:
- CM与右表面杏仁体 (SFA) 和pgACC/PCG之间的rsFC负相关.
- 与身体疏忽有关的SFA-pgACC合;与情感疏忽有关的SFA-PCG合.
- rsFC预测器在两个数据集中准确估计了持续虐待的严重程度.
结论:
- 表面杏仁体 rsFC 与童年虐待有关.
- 这些rsFC可以作为CM相关精神疾病,如抑郁和焦虑的潜在生物标志物.
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