一个大脑结构连接生物标志物用于早期儿童自闭症谱系障碍诊断
Xi Jiang1, Xiao-Jing Shou2,3, Zhongbo Zhao1
1The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China.
Psychoradiology
|April 26, 2024
概括
额叶中的结构性大脑连接差异可以准确地识别患有自闭症谱系障碍 (ASD) 的幼儿. 这些发现可以作为早期生物标志物用于诊断ASD的精准医学.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 医疗成像医学成像
背景情况:
- 自闭症谱系障碍 (ASD) 与大脑发育的改变有关,但需要特定的早期诊断标志物.
- 目前的标记器往往缺乏个别诊断的精度,阻碍了个性化医疗方法.
研究的目的:
- 用扩散张力成像 (DTI) 识别和建模ASD幼儿的大脑结构连接差异.
- 评估这些差异作为ASD准确的个体级别诊断生物标志物的潜力.
主要方法:
- 扩散张力成像 (DTI) 用于测量294个大脑区域的结构连接性 (微分异型,FA).
- 分析了一个发现队列 (93个ASD,26个TD) 和两个验证队列 (12个ASD,9个TD).
- 训练和测试了模式分类模型,以区分自闭症和典型发育 (TD) 的儿童.
主要成果:
- 33个结构连接显示ASD儿童的FA增加,与症状严重程度和认知发育相关.
- 大多数这些改变的连接涉及额叶,并与关键的功能网络联系在一起.
- 分类模型实现了高准确度:96.77% (发现),91.67%和88.89% (验证).
结论:
- 结构性的连接差异,特别是在额叶皮层,准确地区分了ASD个体与TD儿童.
- 这些发现表明,ASD是一个强大的早期大脑生物标志物,适合精准医学应用.
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