在早期抑郁和晚期抑郁的嗅觉功能连接的差异
Ben Chen1,2, Mingfeng Yang1, Meiling Liu1
1Geriatric Neuroscience Center, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province 510370, China.
Psychoradiology
|April 26, 2024
概括
与早期抑郁症 (EOD) 患者相比,晚发性抑郁症 (LOD) 患者在嗅觉区域的嗅觉识别和大脑功能连接 (FC) 减少. 这些嗅觉网络的破坏与LOD的认知障碍有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 晚发性抑郁症 (LOD) 和早期发性抑郁症 (EOD) 有不同的病理机制和临床特征,包括不同程度的嗅觉功能障碍.
- 有助于嗅觉功能障碍的特定大脑异常,EOD和LOD之间的差异尚未得到充分理解.
研究的目的:
- 为了比较EOD和LOD患者之间嗅觉区域的功能连接 (FC) 模式.
- 研究这些患者群体中嗅觉FC和认知功能之间的关系.
主要方法:
- 招募了105名EOD患者,101名LOD患者和160名正常对照 (NC).
- 进行了临床评估,嗅觉测试,认知评估和磁共振成像 (MRI).
- 在八个初级和二级嗅觉区域内分析了FC.
主要成果:
- 与EOD患者和NCs相比,LOD患者的气味识别 (OI) 显著下降.
- 与EOD和NC组相比,LOD组在嗅觉区域 (状皮质,侧侧内皮质,轨道前皮质) 呈现出降低的FC.
- 异常的嗅觉FC与认知功能受损和OI相关,左轨道前皮层-杏仁体FC部分调解了全球认知和OI之间的联系.
结论:
- 与EOD患者相比,LOD患者在初级和二级嗅觉皮层中表现出降低的FC.
- 改变的嗅觉FC与LOD的嗅觉功能障碍和认知缺陷有关.
- 轨道-额叶皮层-杏仁体FC在认知功能和嗅觉识别之间的关系中起着调解作用.
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