目标控制输注:对传统的TCI和基于智能手机的新型应用程序iTIVA进行了比较,前性和观察性研究
Shagun B Shah1, Rajiv Chawla1, Manish Gupta1
1Department of Anaesthesia and Critical Care, Rajiv Gandhi Cancer Institute and Research Centre, Sec-5, Rohini, Delhi, India.
Journal of anaesthesiology, clinical pharmacology
|April 26, 2024
概括
交互式全静脉麻醉 (iTIVA) 软件与传统的目标控制输液 (TCI) 密切匹配,用于提供普罗波. 这证实了iTIVA的存在.
科学领域:
- 麻醉学 麻醉学
- 药理动力学 药理动力学
- 医疗信息学 医疗信息学
背景情况:
- 标准药物剂量不足以解决患者在药理动力学和药理动力学方面的变化.
- 目标控制输注 (TCI) 旨在达到精确的药物度.
- 交互式静脉全麻醉 (iTIVATM) 是智能手机软件,通过多种药理动力学模型模拟TCI.
研究的目的:
- 调查iTIVA软件与传统的TCI (CTP) 之间的协议,用于提供的输液量.
- 评估iTIVA在接受外科手术的成年患者中的临床适用性.
主要方法:
- 一项前性观察性研究,涉及30名成年患者,接受1至3小时的脑外科手术.
- 使用施奈德的药理动力学模型,通过CTP和iTIVA注入的propofol体积的比较.
- 使用了布兰德-阿尔特曼分析和等级相关系数 (斯皮尔曼的rho,肯德尔的tau).
主要成果:
- 在CTP和iTIVA的公醇量之间存在很高的相关性 (斯皮尔曼的rho=0.996,肯德尔的tau=0.964).
- 观察到最小偏差 (-0.02毫升) 和狭窄的协议边界 (-0.63到0.58毫升).
- 观察到的差异处于可接受的临床边际内.
结论:
- iTIVA 软件显示与传统的 TCI 进行普罗波的管理具有高度一致性.
- 这些发现支持iTIVA在全静脉麻醉中的临床适用性和可靠性.
相关概念视频
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