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Updated: Jun 27, 2025

Generation of Cancer Cell Clones to Visualize Telomeric Repeat-containing RNA TERRA Expressed from a Single Telomere in Living Cells
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在基于跨物种位置数据的基础上,根据端粒控制提出候选基因

Elias F Projahn1, Georg Fuellen1, Michael Walter2

  • 1Institute for Biostatistics and Informatics in Medicine and Ageing Research, Rostock University Medical Center, Rostock, Germany.

NAR genomics and bioinformatics
|April 26, 2024
PubMed
概括

这项研究引入了一种计算框架,用于识别受染色体位置影响的基因,特别是靠近端粒的基因. 它有助于研究人员分析基因调节和对位置效应的敏感性,例如长距离端粒位置效应 (TPE-OLD).

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Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
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