在ADHD中的结构连接体
Xuan Bu1,2,3, Miao Cao4,5, Xiaoqi Huang6
1State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China.
Psychoradiology
|April 26, 2024
概括
注意缺陷/多动障碍 (ADHD) 与大脑失联性有关. 扩散MRI研究显示ADHD患者的白质变化,影响症状和认知,但需要更多的研究来临床使用.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 精神病学是一个精神病学.
背景情况:
- 注意缺陷/多动障碍 (ADHD) 越来越多地被视为大脑失联的障碍.
- 在过去十年中,扩散磁共振成像 (dMRI) 研究已经在ADHD患者中确定了白质结构连接体变化.
研究的目的:
- 审查最近在ADHD中基于dMRI的结构连接组研究.
- 综合来自voxel,曲谱和基于网络的分析的发现.
- 探索结构连接体变化的潜力,作为ADHD的生物标志物.
主要方法:
- 基于voxel的dMRI研究的审查.
- 基于路径图的dMRI研究的综述.
- 基于网络的dMRI研究的审查.
主要成果:
- 在ADHD中,前胸道,体,皮质脊髓道和环膜束中的白质微观结构受损.
- 在ADHD结构连接体中,前额头和顶部区域的全球和本地网络效率和节点性质异常.
- 改变的结构连接体显示出预测ADHD症状和帮助诊断分类的潜力.
结论:
- 结构连接体异常是ADHD精神病理学的潜在神经支.
- 这些发现表明在临床ADHD评估中对成像生物标志物有潜力.
- 需要对更大,更均的样本和先进的dMRI技术进行进一步的研究,以验证研究结果并为临床实践提供信息.
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