在接受抗精神病治疗的精神分裂症患者中,不同的神经解剖学亚型根据未经治疗的样本中预定义的分类进行分类
Qiannan Zhao1,2,3, Jiao Li4,5, Yuan Xiao1,2,3
1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, China.
Psychoradiology
|April 26, 2024
概括
神经成像显示,在接受抗精神病治疗的精神分裂症患者中,有三种不同的脑结构亚型,每一种都有独特的认知缺陷. 这些发现强调了在精神分裂症研究中考虑神经生物学异质性的重要性.
科学领域:
- 神经成像和精神病学研究
- 认知神经科学 认知神经科学
背景情况:
- 精神分裂症表现出神经解剖学异质性,特别是在从未接受过治疗的患者中.
- 目前尚不清楚抗精神病药物治疗的患者是否可以使用现有的神经解剖学亚型来分类.
研究的目的:
- 用预定义的分类来研究抗精神病治疗精神分裂症患者的大脑结构的改变.
- 探索这些神经解剖学亚型与认知表现之间的关系.
主要方法:
- 结构性MRI用于从147名接受抗精神病药物治疗的患者中提取皮质厚度,表面积和皮质下体积.
- 认知和症状使用精神分裂症认知简要评估 (BACS) 和正负综合征量表 (PANSS) 进行评估.
主要成果:
- 治疗抗精神病药物的三种亚型患者被确定具有明显的脑形态模式.
- 所有亚型都表现出认知缺陷;然而,神经解剖学和认知异常仅在亚型1 (与符号编码相关的皮质稀释) 中显著相关.
结论:
- 在接受抗精神病药物治疗的精神分裂症患者中,神经解剖学异质性仍然存在,类似于未使用过药物的个体.
- 神经解剖学和认知之间不一致的关联强调了需要考虑精神分裂症研究和临床实践中的异质性.
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