癌症营养免疫疗法与NIR-II激光控制的ATP释放,基于材料重新定位的战略
Jingsong Lu1, Yupei Wang2, Xiaohan Gao3
1Department of Chemistry, Tsinghua University, Beijing 100084, China. lujingsong2022@mail.tsinghua.edu.cn.
Journal of materials chemistry. B
|April 26, 2024
概括
碳酸铁粉 (CIP) 的物质再利用在癌症治疗中显示出前景. 酸盐水凝中的CIP (CIP-ALG) 通过营养铁/光热疗法 (NT/PTT) 和免疫疗法有效治疗瘤.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 瘤表现出异常的铁代谢,呈现出治疗点.
- 碳酸铁粉 (CIP) 是FDA批准的用于治疗贫血的铁补充剂.
- 药物重定向策略在制药领域取得了成功.
研究的目的:
- 探索CIP对抗癌症治疗的物质再利用.
- 评估CIP在芬顿反应,二甲胺素 (DHA) 激活和NIR-II光热疗法 (PTT) 中的疗效.
- 研究营养-光热疗法 (NT/PTT) 和免疫疗法的协同效应.
主要方法:
- CIP的配方是一种可注射的酸盐水凝 (CIP-ALG).
- 在NIR-II激光照射下评估了CIP-ALG的光热效应.
- 在双边瘤模型中评估有效性,评估初级瘤切除和二次瘤抑制.
主要成果:
- 在NIR-II照射下,CIP-ALG凝诱导了快速的温度升高和完全的原发性瘤切除.
- 光热除导致显著的ATP释放.
- 协同NT/PTT治疗导致一次性原发性瘤切除和二次性瘤抑制.
结论:
- 对CIP的物质再利用是一种可行的抗癌策略.
- 通过CIP-ALG介导的NT/PTT与免疫疗法相结合,为安全有效的瘤治疗提供了一种新的方法.
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