不同质的伤口微生物组因伤口护理疼痛,带类型和炎症基因表达而有所不同
Amy Campbell1, Jaewon Bae1, Maria Hein1
1The University of Iowa College of Nursing, Iowa City, Iowa, USA.
概括
带更换期间严重的伤口疼痛可能与特定的细菌有关,而不是炎症. 在经历严重疼痛的患者中发现了较低水平的Corynebacterium和Streptococcus,这表明伤口微生物组在疼痛管理中发挥了作用.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 伤口护理 伤口护理
背景情况:
- 伤口带的改变对于愈合至关重要,但在50%的患者中会引起严重的疼痛.
- 现有的止痛药是不够的,突出需要新的疼痛疗法.
- 伤口病原体和炎症被怀疑是导致伤口疼痛的因素.
研究的目的:
- 调查伤口微生物组组成,炎症标志物和更换包裹时的严重疼痛之间的联系.
- 探索伤口特征,宿主免疫反应和患者报告的疼痛水平之间的关系.
主要方法:
- 445个伤口的探索性横截面分析.
- 使用16S核糖体RNA片序列测序 (406个伤口) 进行细菌组合分析.
- 通过定量实时聚合酶链反应 (qPCR) 量化炎症标记基因表达.
主要成果:
- 在炎症基因表达或临床炎症和严重疼痛之间没有发现任何关联.
- 在严重疼痛的伤口中观察到较低的Corynebacterium和Streptococcus的相对丰度.
- 伤口微生物组组成与炎症标志物相关,并因伤口位置而异.
结论:
- 研究结果表明,伤口微生物组,特别是减少的Corynebacterium和Streptococcus,可能与严重的伤口疼痛有关.
- 初步证据表明,伤口微生物组与真空辅助伤口关闭 (VAC) 之间存在关系.
- 需要进一步的研究来确定伤口微生物群,疼痛和伤口护理技术之间的因果关系.
相关概念视频
Inflammatory Response II: Inflammatory Exudate and Tissue Repair
4.9K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
4.9K
Phases of Wound Repair
6.0K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
6.0K
Inflammation
53.4K
Overview
53.4K
Inflammatory Response
2.0K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.0K
Skin Diseases and Disorders
3.8K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
3.8K
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
4.2K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
4.2K


