细胞死亡相关的分子和目标在尿病的进展 (综述)
Liping Wu1, Xiaoyan Xue1, Chengwu He2
1Department of Pharmacy, Ganzhou People's Hospital, Ganzhou, Jiangxi 341099, P.R. China.
International journal of molecular medicine
|April 26, 2024
概括
结石 (结石) 的发展涉及管细胞损伤和各种类型的细胞死亡. 代谢,特别是三碳酸循环分子,影响石质形成和细胞死亡.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 细胞生物学 细胞生物学
- 生物化学 生物化学
背景情况:
- 尿石是一种常见的疾病,由晶体形成驱动,包括氧化酸盐石头.
- 结石的发病与管细胞损伤,晶体聚合和各种细胞死亡机制 (如亡,铁亡,亡和热亡) 有关.
- 高氧化酸盐或晶体负荷引起的氧化应激是尿病中启动细胞死亡途径的关键因素.
研究的目的:
- 审查目前对结石 (结石) 进展中调控细胞死亡 (RCD) 的理解.
- 为了探索代谢障碍之间的复杂关系,特别是三碳酸循环,和细胞死亡在尿病的背景下.
- 巩固有关不同晶体特性如何影响特定RCD路径的知识.
主要方法:
- 关于尿病,细胞死亡和新陈代谢的研究的综合文献综述.
- 分析各种细胞死亡类型中涉及的信号通路和分子交叉声.
- 检查像酸盐和酸盐这样的代谢分子在石头发育和细胞死亡抑制中的作用.
主要成果:
- 不同的晶体类型,度和形态会诱导不同的管状细胞死亡形式.
- 氧化应激是尿病中多个细胞死亡模式的重要前体.
- 代谢因素,包括三酸循环中间体,在调节细胞死亡和抑制结石形成方面发挥着至关重要的作用.
结论:
- 调节的细胞死亡途径是结石发育和进展的组成部分.
- 代谢失调与尿病中的细胞死亡机制密切相关.
- 对新陈代谢和RCD之间的相互作用进行进一步的研究可能会揭示尿病的新治疗策略.
相关概念视频
01:31The Intrinsic Apoptotic Pathway
6.5K
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
6.5K
01:30Overview of Cell Death
7.3K
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
7.3K
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
01:17The Extrinsic Apoptotic Pathway
6.3K
The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
6.3K