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自闭症谱系障碍中的益生菌:来自动物模型的最新见解

Navid Golbaghi¹, Saeideh Naeimi², Afra Darvishi³

¹Department of Comparative Biosciences, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran.

Autism : the international journal of research and practice

|April 26, 2024

概括

益生菌疗法对通过积极影响肠道微生物平衡来管理自闭症谱系障碍 (ASD) 有前途. 动物研究表明,益生菌可以改善氧化应激和炎症,为ASD治疗提供潜在的新途径.

科学领域:

神经科学是一个神经科学.
微生物学微生物学
胃肠病学胃肠病学

背景情况:

自闭症谱系障碍 (ASD) 是一种带有行为变化的神经发育状况.
目前用于ASD的药理疗法通常是无效的,并引起副作用.
肠道微生物组合的变化在患有自闭症的个体中观察到.

研究的目的:

探索益生菌在管理和治疗自闭症谱系障碍方面的潜力.
审查最近关于ASD益生菌干预的临床前研究.

主要方法:

审查最近的临床前研究研究益生菌疗法在动物模型的ASD.
对专注于ASD肠道微生物变化的研究进行分析.

主要成果:

益生菌治疗在临床前研究中表现出有利的结果.
在氧化应激,炎症和神经递质调节方面注意到了改善.
益生菌有助于恢复动物模型中的微生物平衡.

结论:

益生菌干预显示出治疗自闭症谱系障碍的潜力.
对肠道微生物群调节的进一步研究可能会导致ASD的新型治疗策略.

关键词:

自闭症谱系障碍自闭症谱系障碍牛乳杆菌 (Lactobacillus) 是一种细菌.动物模型动物模型肠-大脑轴肠-大脑轴益生菌是一种益生菌.

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相关概念视频

Autism Spectrum Disorder

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.