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Updated: Jun 27, 2025

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
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Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides

Published on: May 26, 2019

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合作性黄金 (I) /DMAP催化启用 (2 + 3) Yne-Enones的循环添加与来自氧的MBH碳酸盐

Hongli Zhao1, Laiping Yao1, Yiqiao Gu1

  • 1State Key Laboratory of Southwestern Chinese Medicine Resources, Hospital of Chengdu University of Traditional Chinese Medicine, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, P.R. China.

Organic letters
|April 26, 2024
PubMed
概括

一种新型的黄金 (I) /DMAP合作催化使因子和 Morita-Baylis-Hillman碳酸盐能够有效 (2+3) 循环添加. 这种方法可以产生具有高选择性的多样化的bispiro-cyclopentene oxindoles.

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The Diels–Alder reaction is an example of a thermal pericyclic reaction between a conjugated diene and an alkene or alkyne, commonly referred to as a dienophile. The reaction involves a concerted movement of six π electrons, four from the diene and two from the dienophile, forming an unsaturated six-membered ring. As a result, these reactions are classified as [4+2] cycloadditions.
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Robinson annulation is a base-catalyzed reaction for the synthesis of 2-cyclohexenone derivatives from 1,3-dicarbonyl donors (such as cyclic diketones, β-ketoesters, or β-diketones) and α,β-unsaturated carbonyl acceptors. Named after Sir Robert Robinson, who discovered it, this reaction yields a six-membered ring with three new C–C bonds (two σ bonds and one π bond).
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