一个全面的青少年糖尿病流行病学数据集和网站门户:资源开发和案例研究
Catherine McDonough1, Yan Chak Li1, Nita Vangeepuram2,3
1Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
JMIR public health and surveillance
|April 26, 2024
概括
年轻人中2型糖尿病和糖尿病前期的发病率不断上升,需要了解风险因素. 这项研究创建了一个全面的数据集和一个网络门户网站 (POND) 来分享发现,并促进对青少年糖尿病和糖尿病的研究.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 数据科学数据科学数据科学
背景情况:
- 在美国青年中,2型糖尿病 (DM) 和糖尿病前期 (DM前期) 的患病率增加.
- 迫切需要确定相关的风险因素.
- 缺乏可访问的青少年DM前/DM数据阻碍了研究.
研究的目的:
- 建立一个高质量的,全面的流行病学数据集,为青少年DM/DM前.
- 通过用户友好的网络门户网站使数据可访问,以促进研究.
- 解决青年DM前/DM前数据和研究的差距.
主要方法:
- 利用了国家健康和营养检查调查 (NHANES) 数据 (1999-2018) 对12-19岁的年轻人.
- 清理和协调了DM前/DM前的相关变量.
- 采用双变量统计分析和集成集成 (EI) 机器学习框架.
- 开发了前糖尿病/青少年糖尿病在线仪表板 (POND) 用于数据和代码共享.
主要成果:
- 在社会人口统计,健康状况,饮食和生活方式领域提取了95个变量.
- 确定了27个显著的DM前/DM相关物 (例如BMI,添加糖摄入量,屏幕时间).
- EI框架确定了16个重叠变量和11个额外的预测变量,涵盖所有领域.
结论:
- 开发了最大的公共流行病学数据集之一,用于DM/DM前的青少年.
- 识别了各种领域的多因素风险因素.
- 该POND平台促进了未来的青年前DM/DM研究和应用.
相关概念视频
Diabetes Mellitus: Overview and Type I Subtype
2.6K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.6K
Diabetes: Symptoms, Diagnosis, and Complications
526
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
526
Diabetes Mellitus: Type 2 and Gestational
2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
Diabetes: Management and Pharmacotherapy
268
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
268
Statistical Software for Data Analysis and Clinical Trials
540
Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
540
Pathophysiology of Diabetes
922
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
922


