相关实验视频
Updated: Jun 28, 2026

10:30
A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy
Published on: May 16, 2015
19.6K
菌体尾酒对健康的断奶小猪的系统性影响
Yankun Liu1,2, Yan Lin1,2,3, Weiyun Zhu1,2,3
1Laboratory of Gastrointestinal Microbiology, Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Biology
|April 26, 2024
概括
口腔菌体 (菌体) 显示复杂的系统性作用,增强肠道屏障功能和改变免疫反应,而不会对小猪生长产生负面影响. 需要进一步的研究才能充分了解菌体对整体健康的影响.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 动物科学动物科学
背景情况:
- 菌体 (菌体) 对肠道细菌感染有效.
- 有限的研究存在于口服菌体对全身健康的影响.
- 了解肠道以外的菌体影响对于治疗应用至关重要.
研究的目的:
- 为了评估口服菌素尾酒对断奶小猪的全身健康影响.
- 研究菌体对生长,器官指数,肠道环境和免疫状态的影响.
- 在哺乳动物模型中评估菌体治疗的安全性和有效性.
主要方法:
- 断奶小猪口服了一种菌体尾酒,向沙门氏菌和大肠杆菌,持续20天.
- 分析了生长性能,血清生物化学,器官指数,肠道血清 pH 和微生物群.
- 测量了免疫细胞数量,血清细胞因子水平和通类受体 (TLR) 激活.
主要成果:
- 菌体测量没有影响生长,血清生物化学或大多数器官指数,除了胰腺指数下降.
- 菌体增强了肠道屏障功能,改变了微生物群,增加了特定的短链脂肪酸.
- 观察到免疫状况的显著变化,包括免疫球蛋白增加,促炎细胞因子和TLR激活,抗炎细胞因子减少.
结论:
- 在小猪中短期口服菌体,没有显著的负面健康影响.
- 菌体可以增强肠道屏障功能,调节免疫系统.
- 菌体的复杂系统性影响,特别是免疫力,需要进一步研究.
更多相关视频
相关概念视频
Microbes in Food Production
Microbial fermentation is central to food biotechnology, enhancing flavor, texture, preservation, and stability. Fermentative microorganisms metabolize carbohydrates into organic acids, alcohols, and other metabolites that inhibit spoilage organisms and improve digestibility while contributing distinctive sensory qualities.In baking, amylases naturally present in flour hydrolyze starch into monosaccharides such as glucose, which Saccharomyces cerevisiae ferments anaerobically. Through...
Microbes in Beverage Production
Alcoholic beverages such as wine, beer, and spirits are the products of microbial fermentation processes that transform simple sugars into ethanol and a wide array of complex flavor compounds. These transformations rely on the metabolic activities of specific yeasts and bacteria, which are selected and controlled to yield the desired beverage characteristics.Wine Fermentation and MaturationWine production begins with the crushing of grapes to release juice and pulp, forming a must that is...
Microbes in the Production of Fermented Foods
Lactic acid bacteria (LAB) and molds are instrumental in fermenting plant-based foods to enhance preservation and ensure year-round availability. These microbial processes convert plant carbohydrates into organic acids and other metabolites that inhibit spoilage organisms and contribute to the sensory qualities of the final product.In sauerkraut production, cabbage goes through a microbial succession that starts with cocci such as Leuconostoc mesenteroides. These microbes begin fermentation by...
Development of Human Microbiota
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
Dysbiosis of the Gut Microbiota
The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
Microbiota Modulation by Antibiotics
Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...

