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通过SynNotch受体工程提高自然杀手细胞的抗瘤效率,以准IL-12分泌

Ali Ahmadnia1, Saeed Mohammadi2, Ahad Yamchi3

  • 1Department of Molecular Medicine, Faculty of Advanced Medical Technologies, Golestan University of Medical Sciences, Gorgan P.O. Box 665, Iran.

Current issues in molecular biology
|April 26, 2024
PubMed
概括

带有PD1合成Notch (synNotch) 受体的工程自然杀手 (NK) 细胞显示出增强的抗瘤活性. 这种方法可以提高NK细胞的细胞毒性和细胞因子的产生,对抗PD-L1阳性乳腺癌细胞.

关键词:
IFNγ IFNγ 的意思在IL-12中,IL-12是最重要的.在 NK 细胞中, NK 细胞是最重要的.乳腺癌 乳腺癌 乳腺癌癌症免疫疗法免疫疗法细胞毒性 细胞毒性这是一个synNotch受体.

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