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相关概念视频

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
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通过元分析来定义型结肠炎中差异表达的lncRNAs的参考集的挑战

Christopher G Fenton1,2, Mithlesh Kumar Ray1, Ruth H Paulssen1,2

  • 1Clinical Bioinformatics Research Group, Department of Clinical Medicine, UiT-The Arctic University of Norway, N-9037 Tromsø, Norway.

Current issues in molecular biology
|April 26, 2024
PubMed
概括

研究人员使用基因表达数据在性结肠炎 (UC) 中确定了19种常见的差异表达长非编码RNA (lncRNAs). 这些lncRNAs可以作为活跃UC的生物标志物,并与结直肠癌的进展有关.

关键词:
在 LncRNAs 中.这是一个元分析.性结肠炎是一种

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科学领域:

  • 胃肠病学 胃肠病学
  • 分子生物学分子生物学
  • 生物信息学是一种生物信息学.

背景情况:

  • 性结肠炎 (UC) 是一种慢性炎症性肠病.
  • 确定活跃UC的可靠生物标志物对于患者管理至关重要.
  • 长非编码RNAs (lncRNAs) 在各种生物过程和疾病中发挥作用.

研究的目的:

  • 使用公开可用的基因表达数据集,识别性结肠炎 (UC) 中常见的差异表达的lncRNAs.
  • 探索这些lncRNAs作为活跃UC生物标志物的潜力.
  • 研究已识别的lncRNAs与结直肠癌 (CRC) 途径的关联.

主要方法:

  • 从Gene Expression Omnibus (GEO) 的九个人类结肠活检转录数据集的手动策划.
  • 使用R包 (geneknitR,gprofiler,clusterProfiler) 来进行基因符号注释.
  • 使用R EdgeR包进行差异表达分析,以识别至少三组数据中存在的lncRNA.

主要成果:

  • 在多个UC GEO数据集中识别了19个差异表达的lncRNAs.
  • 一些已识别的lncRNA与结直肠癌 (CRC) 的进展有关,包括调节基因表达,表皮细胞转化为介质细胞转化 (EMT),细胞周期,增殖,入侵和迁移.
  • 根据疾病状态和UC内的组织位置观察到lncRNA表达的变化.

结论:

  • 已识别的19个lncRNAs可以作为活跃性结肠炎的一般生物标志物,独立于活检位置,年龄,性别或治疗.
  • 这些发现为未来的研究和使用现有的GEO UC数据集进行比较提供了宝贵的资源.
  • 鉴定到的lncRNA与CRC通路的关联需要进一步研究它们在炎症和癌症中的双重作用.