埃奇纳西亚通过预防呼吸道感染来减少抗生素:一个元分析 (ERA-PRIMA)
Giuseppe Gancitano1,2, Nicola Mucci2, Rainer Stange3
11st Carabinieri Paratrooper Regiment "Tuscania", Italian Ministry of Defence, 57127 Livorno, Italy.
Antibiotics (Basel, Switzerland)
|April 26, 2024
概括
可以显著减少呼吸道感染 (RTIs) 和对抗生素的需求. 这种草药在预防RTIs及其并发症方面是安全有效的,特定的制剂显示出更强的效果.
科学领域:
- 草药是一种草药.
- 预防传染病 预防传染病
- 药理学 药理学是指药理学的学科.
背景情况:
- 呼吸道感染 (RTIs) 是抗生素处方的主要驱动因素.
- 二次性细菌感染在RTIs中构成重大风险.
- 预防RTIs可以减少抗生素的使用,并打击抗菌素耐药性.
研究的目的:
- 评估 Echinacea 在预防 RTIs 和其并发症方面的有效性.
- 评估埃奇纳西亚在RTI预防中的安全性.
- 为了确定 Echinacea 是否可以减少对抗生素治疗的需要.
主要方法:
- 一项对30项涉及5652名受试者的临床试验的系统审查和元分析.
- 搜索的数据库:EMBASE,PubMed,谷歌学者,Cochrane DARE,clinicaltrials.gov.gov,这些数据库中的一个是
- 分析了关于RTI发生,并发症,抗生素使用和不良事件的数据.
主要成果:
- 秋草显著降低了每月RTI发生率 (RR=0.68) 和RTIs患者数量 (RR=0.75).
- 降低了复发性感染 (RR=0.60),RTI并发症 (RR=0.44) 和需要抗生素治疗 (RR=0.60) 的风险.
- 酒精的紫 Echinacea 提取物显示出最强的效果,减少了80%的抗生素日 (IRR=0.21).
- 在 Echinacea 和对照组之间,不良事件发生率相似.
结论:
- 可以安全有效地预防RTIs和相关并发症.
- 草的使用可以减少对抗生素治疗的需求.
- Echinacea 制剂的变化会影响其有效性.
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