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大麻的抗微生物,益生菌和免疫调节潜力提取和输送系统

Anna Stasiłowicz-Krzemień¹, Daria Szymanowska^1,2, Piotr Szulc³

¹Department of Pharmacognosy and Biomaterials, Faculty of Pharmacy, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland.

Antibiotics (Basel, Switzerland)

|April 26, 2024

概括

大麻提取物表现出广泛的抗微生物和益生菌作用,增强有益细菌的生长. 它还通过改变细胞因子水平来调节免疫反应,显示出治疗应用的潜力.

科学领域:

植物化学和药理学
微生物学和免疫学

背景情况:

大麻 (Cannabis sativae) 含有二次代谢物,如大麻素,烯和黄类.
这些化合物表现出协同作用的生物活性,包括抗微生物,益生菌和免疫调节作用.
该研究调查了特定的麻提取物 (Henola) 和其配方的潜力.

研究的目的:

评估汉诺拉大麻树提取物的抗微生物,益生菌和免疫生物学的活性.
评估所选载体 (聚乙烯烯酸-聚乙烯酸-聚乙烯甘醇移植共聚合物,氧化酸和基-β-环氧化) 对提取物的活性的影响.

主要方法:

抗微生物活性被测试在一个由致病性细菌和真菌组成的小组中.
用有益细菌菌株评估益生菌潜力,测量增长促进.
通过分析关键细胞因子水平 (IL-6,IL-8,TNF-α) 的变化来评估免疫调节效应.

主要成果:

大麻提取物对测试的病原体表现出显著的抗微生物活性,大大减少了微生物的数量.
配合基烯-β-环氧的配方显示出显著的益生菌潜力,显著增加了有益细菌的生长.
提取物及其配方都诱导了IL-6,IL-8和TNF-α水平的可测量变化,表明免疫调节作用.

结论:

汉诺拉Cannabis sativae提取物具有显著的抗微生物和益生菌特性.
配合基 propyl-β-cyclodextrin 的配方增强了大麻提取物的益生菌潜力.
提取物及其配方在调节免疫反应方面表现有前途,因此需要进一步研究治疗应用.

关键词:

大麻sativa是一种大麻.它是一种抗菌药物,具有抗菌作用.在Cannabidiol中使用.这是一种免疫调节剂.这是一种免疫刺激药.益生菌是一种益生菌.

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